TA15 titanium alloy is the key material of large aviation structural parts. Hot isostatic pressing (HIP) technology is effective for realizing near net shape formation of high-performance powder titanium alloys. However, the coarsening of the microstructure during the HIP process often leads to an imbalance between strength and plasticity. The purpose of this study is to explore the influence of HIP process parameters on the microstructure evolution and tensile properties of powder TA15 alloys to provide theoretical support for the optimization of the process window. To address the issues of microstructure coarsening and performance imbalance during hot isostatic pressing (HIP) of powder metallurgy TA15 alloys. The effects of temperature (890~980 ℃)and holding time (2~6 h) on the microstructure and tensile properties of the samples were systematically investigated. The results indicate that all the samples achieve full densification, whereas the microstructure evolution is governed primarily by the HIP temperature. Distinct prior particle boundaries (prior particle boundaries, PPBs) are present at a low temperature (890 ℃ ), forming a fine basket-weave α microstructure, which corresponds to a relatively high yield strength (966 MPa). As the temperature increases, the PPBs gradually disappear, whereas the α laths and their colony structures coarsen significantly, leading to a continuous decrease in strength. When the temperature approaches the β-transus (980 ℃ ), the β phase fraction increases, leading to further weakening of the mechanical properties. In contrast, the holding time affects mainly the degree of microstructure coarsening but affects the mechanical properties. Comprehensive analysis reveals that optimal strength-ductility synergy can be achieved under the conditions of 920 ℃-120 MPa-4 h.