The effects of Ti and Zr microalloying on the solidification process, microstructure, and mechanical properties of an as-cast Al-6Ni eutectic alloy were investigated. The results show that the microstructure of the Al-6Ni eutectic alloy cast in the permanent mold is composed of a primary α-Al phase and an (α-Al+Al3 Ni) eutectic. The primary α-Al phase nucleates on the compounds containing Ti and Zr, resulting in a decrease in undercooling and an increase in the nucleation temperature. When adding 0.3 wt.% Ti+0.3 wt.% Zr, the nucleation temperature of the Al-6Ni alloy increases from 632 ℃ to 638.5 ℃. The eutectic solidification time gradually decreases with the addition of Ti and Zr, but there is no significant change in the morphology or size of the eutectic Al3 Ni phase. When the amount of Ti and Zr added is relatively high, a small amount of strip-shaped Al3 (Ti, Zr) phase and blocky Al3 Ni phase are formed at the eutectic boundaries. The tensile strength, yield strength and elongation of the Al-6Ni alloy with the addition of 0.2 wt.% Ti+0.2 wt.% Zr are 140 MPa, 82 MPa and 26%, respectively, which are 8%, 25% and 61% greater than those of the Al-6Ni alloy. The fracture surface is composed of tear ridges, dimples and a small number of cleavage planes, with ductile fracture being the main type.