To address the current challenges of difficult process control, low product qualification rates, and significant performance disparities among various sections in large complex die-castings, the effects of pouring temperature and mold temperature on the microstructure and properties of die-castings were investigated via an integrated computational platform guided by the concept of material genetic engineering. The experimental preparation was carried out via the parameters used in the simulation, and the effects of different filling distances on the microstructure and properties of the materials were further studied. The results show that with increasing mold temperature, the melt flow ability increases, the grain size increases, and the porosity decreases. Similarly, with increasing pouring temperature, the melt flow ability, grain size and porosity increase. When the pouring temperature is 750 ℃ and the mold temperature is 250 ℃, the alloy has good filling ability and microstructure. The analysis of microstructure and mechanical properties under different filling distances shows that with increasing filling distance, the area fraction of ESCs (externally solidified crystals) decreases, and their morphology changes from coarse dendrites to broken dendrites, strips and spheres. The porosity first decreases but then increases, and the mechanical properties first increase but then decrease. The material still has good mechanical properties at 650 mm, indicating that the maximum allowable filling distance of the Al-7Si-Mg-Cu alloy reaches 650 mm under this process.