Taking the whole valve sand mold (core) as an example, the current situation of 3D printing in the production of enterprises from the aspects of printing equipment, process formulation, quality assessment, etc. were expounded, and the application of 3D printing in valve sand mold casting was introduced. The results show that the surface of the 3D sand mold (core) is smooth, the model has the step effect, and the strength of the sand mold meets the production demand. Using 3DP technology and casting process, the material of Z3CN20-09M, 6J300 nuclear globe valve is produced. The casting dimensional accuracy and surface quality are good. The RT and PT test are qualified, which verifies the feasibility of the process.