The abnormal macrostructure of titanium forgings containing Fe is common in production. The abnormal macrostructures of the multicomponent titanium alloys TB6 and TC18 were studied via optical microscope (OM), energy spectrum analysis (EDS), ICP spectral analysis, etc. The results reveals that the bright spots in the region from the 1/2 radius to the center of the TB6 alloy bar, and the dark spots in the central area of the head of the TC18 alloy bar are both Fe enrichment segregations formed during the ingot melting process. Further analysis reveals that Fe segregation is caused by the solute partition coefficient k0 <1. The Fe segregation in the production process of the ingot can be effectively prevented by adopting a lower melting current, shortening the feeding time, and controlling the arc-stabilizing current.